ea0033oc4.6 | Oral Communications 4 | BSPED2013
Sirka Ernestas
, Manwaring Victoria
, Peters Catherine
, Amin Rakesh
, Heywood Wendy
, Hindmarsh Peter
, Mills Kevin
Nephropathy remains a major diabetes related complication despite improvements in metabolic control. Current interventions are based on the appearance of albuminuria. Whether earlier detection and treatment might be beneficial is unclear. The reabsorption of low molecular weight (<70 kDa) plasma proteins in the renal proximal tubule is mediated by an endocytic receptor, megalin, and its coreceptor, cubulin.Using label free quantitative proteomics we ...